Anistreplase


Concise Prescribing Info
Indications/Uses
Thromboembolic disorders.
Dosage/Direction for Use
Adult : IV 30 u as a single inj immediately after onset of symptoms.
Dosage Details
Intravenous
Thromboembolic disorders
Adult: 30 u over 5 minutes as a single inj, as soon as possible after onset of symptoms.
Contraindications
Increased risk of cerebral bleeding including severe hypertension, haemorrhage, recent stroke. Cerebral neoplasm, pregnancy.
Special Precautions
Patients with increased risk of bleeding. Active internal bleeding, recent history of peptic ulcer, esophageal varices, ulcerative colitis, other bleeding GI lesions, pancreatitis, subacute bacterial endocarditis, coagulation defects, invasive procedures, mitral stenosis associated with atrial fibrillation. Elderly, diabetic retinopathy.
Adverse Reactions
Allergic reactions; fever; nausea and vomiting; haemorrhage; hypotension; pulmonary embolism, acute renal failure, Gullain-Barre syndrome.
Potentially Fatal: Severe internal bleeding.
Drug Interactions
Increased risk of haemorrhage with heparin, oral anticoagulants, antiplatelet drugs and other drugs that can affect platelet function.
Action
Description: Anistreplase consists of a complex of the lys-form of plasminogen and streptokinase with the addition of a p-anisoyl group that undergoes deacylation upon iv Inj to release the active complex which converts plasminogen to plasmin which has fibrinolytic activity.
Disclaimer: This information is independently developed by MIMS based on Anistreplase from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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