Prophylaxis of perioperative blood loss in patients undergoing coronary artery bypass graft
Adult: Administer 10,000 KIU test dose 10 minutes before surgery. Loading dose: 1,000,000-2,000,000 KIU via slow IV inj or infusion over 20-30 minutes after induction of anaesthesia, followed by 250,000-500,000 KIU/hour via continuous infusion until end of the operation. An additional dose of 1,000,000-2,000,000 KIU is added to the pump prime of the heart-lung machine. Max: 7,000,000 KIU. Max rate: 5-10 mL/min.