Artrodar

Artrodar

diacerein

Manufacturer:

TRB Chemedica

Distributor:

DKSH

Marketer:

TRB Chemedica
Concise Prescribing Info
Contents
Diacerein
Indications/Uses
Degenerative joint diseases (OA & related diseases). Relief or improvement of OA symptoms eg, pain, inflammation & joint impairment. Long-term treatment can slow down disease progression & preserve articular cartilage. Alternative medication in patients who do not respond to other OA treatments &/or patients who present contraindications to joint replacement/surgery, NSAIDs & those w/ CV problems in whom NSAIDs are contraindicated.
Dosage/Direction for Use
1 cap once daily or bd for at least 3 mth; or 1 cap daily for 2-4 wk, in patients w/ loose stools &/or diarrhea due to acceleration of intestinal transit time. May be increased to 2 cap daily (1 cap bd). May be co-prescribed w/ a NSAID or analgesic for 1st 2-4 wk of treatment, due to late onset of action for pain relief. Duration of treatment: Symptomatic effects: Take continuously for at least 3 mth & can be repeated if symptoms reappear; long-term treatment is recommended for preservation of articular cartilage & to delay disease progression.
Administration
Should be taken with food: Take w/ or immediately after meals.
Contraindications
Hypersensitivity to diacerein or other anthraquinone derivatives. Consider temporary treatment suspension in case of concomitant antibiotic therapy. May cause intestinal transit time acceleration during early period of treatment; caution in those w/ previous episodes of enterocolic disturbances eg, irritable colon. Inflammatory intestinal disease (eg, ulcerative colitis, Crohn's disease), intestinal obstruction or pseudo-obstruction, painful abdominal syndromes of undetermined cause & severe liver disease.
Special Precautions
Severe nutritional deficiencies decrease bioavailability. May lead to loose stool &/or diarrhea at start of treatment; discontinue treatment if unusually frequent liquid or watery stool is experienced. Dehydration & hypokalemia may occur during concomitant use w/ diuretics. Particular caution in case of hypokalemia during concomitant use w/ cardiac glycosides (eg, digitoxin, digoxin). Should not be taken concomitantly w/ laxatives, especially during the 1st 2-4 wk of treatment. May result in intense yellow urine coloration; increase in water intake is recommended. Comorbid conditions & past or concurrent liver disease; screen for major causes of active hepatic disease. Contraindicated in patients w/ severe liver disease. Monitor for signs of hepatic injury; caution in concomitant use w/ drugs associated w/ hepatic injury. Limit alcohol intake while on treatment. Discontinue if symptoms suggestive or liver damage arise (abdominal pain, jaundice, pruritus & increased liver enzyme). Severe renal insufficiency. Do not use during pregnancy & lactation. Not for childn <18 yr. Elderly ≥65 yr.
Adverse Reactions
Diarrhea, abdominal pain, frequent bowel movements & flatulence. Few cases of liver disorders eg, elevated serum liver enzymes including hepatitis (monitor patients for signs & symptoms of hepatic injury). Some cases of pruritus, rash & eczema.
Drug Interactions
Do not use w/ drugs that modify intestinal transit &/or quality of intestinal content (eg, excess fibers or phytates). Concomitant use of Mg, Al or Ca-based antacids should have a min interval of 2 hr to maximize the bioavailability. May increase enterocolic events in patients undergoing treatment w/ some antibiotics eg, amoxicillin/clavulanic acid &/or chemotherapy. Increased risk of arrhythmia w/ diuretics (high-ceiling loop & thiazides) &/or cardiac glycosides (digitoxin, digoxin).
ATC Classification
M01AX21 - diacerein ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
Presentation/Packing
Form
Artrodar cap 50 mg
Packing/Price
3 × 10's
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