Diarrhea, abdominal pain, frequent bowel movements and flatulence are the most frequently reported side effects associated with ARTRODAR treatment. As a rule, these effects abate with continuing treatment. In some cases, diarrhea was severe with complications such as dehydration and disorders of fluid and electrolyte balance. However, results from a clinical study showed that starting treatment with one capsule per day with meals for the first 4 weeks can decrease the undesirable effects of accelerated intestinal transit time.
The intake of ARTRODAR may sometimes result in a more intense yellow coloring of the urine. This is typical of the type of compound (anthraquinone) and is of no clinical significance. Thus, it is recommended to drink a lot of water which will decrease the intensity of urine discoloration.
Based on pharmacovigilance data, a few cases of liver disorders such as elevated serum liver enzymes including hepatitis have been reported. Most of them occurred during the first months of treatment. Although the incidence is very rare, patients should be monitored for signs and symptoms of hepatic injury.
Cutaneous effects: some cases of pruritus, rash and eczema have been reported.