Diacerein must not be administered at the same time as drugs that modify intestinal transit and/or the quality of the intestinal content (e.g. excess fibers or phytates) especially during the first 2-4 weeks of treatment. In case of concomitant use of magnesium, aluminium or calcium-based antacids, there should be a minimum time interval of 2 hours between the intake of any of these preparations and ARTRODAR, in order to maximize the bioavailability of diacerein. Treatment with diacerein may cause an increase in enterocolic events in patients undergoing treatment with some antibiotics such as amoxicillin/clavulanic acid and/or chemotherapy which could affect the intestinal flora. During the first 2-4 weeks of treatment, intake of diacerein can in some cases lead to severe diarrhea and hypokalemia. Caution must be exercised in the concomitant administration of diuretics (high-ceiling loop and thiazides) and/or cardiac glycosides (digitoxin, digoxin), as the risk of arrhythmia is increased.