Aspirin + Vitamin C


Concise Prescribing Info
Indications/Uses
Mild to moderate pain and fever
Dosage/Direction for Use
Adult : PO Each effervescent tab contains aspirin 400 mg and ascorbic acid 240 mg: 1-2 tabs 4-8 hourly if needed. Max: 3-6 tabs daily.
Dosage Details
Oral
Mild to moderate pain and fever
Adult: Available preparation
Each effervescent tab contains aspirin 400 mg and ascorbic acid 240 mg.
1-2 tabs, may repeat 4-8 hourly, if necessary. Max: 3-6 tabs daily.
Contraindications
Gastric or duodenal ulcers. Haemophilia, thrombocytopenia or other bleeding tendencies; patients receiving anti-coagulant treatment. Hypersensitivity to aspirin or other salicylates or ascorbic acid. Severe renal impairment.
Special Precautions
Risk of Reye's syndrome in children with varicella infection or influenza-like illnesses. Not to be used for >10 days without medical advice. Treatment should be withdrawn 1 wk prior to surgery to prevent or reduce risk of bleeding complications. Caution when used in patients with impaired renal function, severe hepatic impairment, history of GI disorders e.g. peptic ulcers, ulcerative colitis and Crohn's disease, dyspepsia and when the patient is dehydrated. Pregnancy and lactation.
Adverse Reactions
Dizziness, GI irritation e.g. dyspepsia, nausea, vomiting, erosion, ulceration, haematemesis and melaena. Prolonged use of high doses of aspirin may cause anaemia, blood dyscrasia, GI haemorrhage and peptic ulceration.
Overdosage
Overdose of aspirin can lead to dizziness, tinnitus, sweating, nausea, vomiting, altered glucose metabolism, mental confusion, hyperventilation, respiratory alkalosis, metabolic acidosis, ketosis, fluid and electrolyte losses. CNS depression may lead to coma, CV collapse and respiratory failure. Overdosage of vitamin C may lead to diarrhoea and GI disturbances. Treatment includes gastric lavage, forced alkaline diuresis, restoration of fluid, electrolyte and acid balance, dialysis and supportive therapy may be needed.
Drug Interactions
Aspirin may increase hypoprothrombinemic effect of warfarin and other oral anticoagulants, thus increasing the risk of bleeding complications. May antagonise uricosuric effect of probenecid, phenylbutazone or sulfinpyrazone. Concurrent admin with corticosteroids may reduce the serum levels of aspirin. Aspirin may increase serum levels of methotrexate. Concurrent admin with alcohol increases risk and severity of GI bleeding and ulceration. Aspirin may reduce the absorption of vitamin C.
Lab Interference
May falsely elevate results for blood creatinine, urate (low dose aspirin) and urea and falsely decrease results for blood thyroxine, urate and urinary 5-hydroxyindoleacetic acid (with nitrosonapthol method). Urinary vanillylmandelic acid (or 4-hydroxy-3-methoxymandelic acid) levels may be falsely increased or decreased depending on the method of analysis.
Action
Description: Aspirin has pain-relieving, anti-pyretic and anti-inflammatory actions. Vitamin C is a water-soluble vitamin that is used with aspirin for the relief of pain and/or fever associated with colds and flu.
Pharmacokinetics:
Absorption: Vitamin C: Readily absorbed via oral admin.
Metabolism: Vitamin C: Hepatic via oxidation and sulfation.
Storage
Store below 25°C.
Disclaimer: This information is independently developed by MIMS based on Aspirin + Vitamin C from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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