Augpac/Augpac Injection

Augpac/Augpac Injection

amoxicillin + clavulanic acid

Manufacturer:

Pacific Pharma (Korea)

Distributor:

AA Medical
Concise Prescribing Info
Contents
Co-amoxiclav (amoxicillin, clavulanic acid) Per Augpac FC tab 375 mg Amoxicillin 250 mg, clavulanic acid 125 mg. Per Augpac FC tab 625 mg Amoxicillin 500 mg, clavulanic acid 125 mg. Per Augpac Injection powd for inj Amoxicillin 500 mg, clavulanic acid 100 mg
Indications/Uses
Upper resp tract infections (eg, otitis media, tonsillitis, sinusitis); lower resp tract infections (eg, bronchitis, pneumonia); UTI (cystitis, urethritis, pyelonephritis); skin & soft tissue infections (eg, severe dental abscess, wound infections, cellulitis).
Dosage/Direction for Use
Augpac Adult Severe & resp tract infection 1 tab 8 hrly. Childn 25-50 mg/kg/day of 625-mg FC tab taken in divided doses 8 hrly. Augpac Injection Adult & childn >12 yr 1.2 g 8 hrly. Severe infections Increase to 6 hrly intervals. Childn 3 mth to 12 yr 30 mg/kg 8 hrly. Severe infections Increase to 6 hrly intervals. 0-3 mth 30 mg/kg 12 hrly in premature infants & in full-term infants during the perinatal period, increasing to 8 hrly thereafter.
Administration
May be taken with or without food: Best taken at the start of meals for better absorption & to reduce GI discomfort.
Contraindications
Hypersensitivity to penicillins & cephalosporins. Previous history of amoxicillin & K clavulanate associated jaundice/hepatic dysfunction. Augpac Infectious mononucleosis. Patients w/ lymphatic leukemia & patients w/ hyperuricaemia treated w/ allopurinol. Augpac Injection Cross-sensitivity w/ other β-lactams, eg, cephalosporins.
Special Precautions
Penicillin hypersensitivity; history of multi-allergen sensitivity. Patients w/ evidence of hepatic dysfunction. Augpac May impair ability to drive or operate machinery. Pregnancy. Augpac Injection Patients w/ kidney dysfunction. Not for IM administration. Lost stability w/ infusions containing glucose, dextran or bicarbonate. Avoid use during pregnancy.
Adverse Reactions
Hepatitis & cholestatic jaundice. Augpac Skin rashes. Potentially fatal, anaphylaxis. Augpac Injection Urticarial & erythematous rashes; nausea, vomiting, diarrhoea, indigestion; moderate rises in AST &/or ALT.
Drug Interactions
Amoxicillin: Increased incidence of allergic skin reactions w/ concomitant use of allopurinol. Augpac Coumarin or indandione-derivative anticoagulants; heparin; NSAIDs especially, aspirin; other platelet aggregation inhibitors or thrombolytic agents. May decrease efficacy of oestrogen-containing OCs. Augpac Injection Prolonged bleeding time & prothrombin time in patients on anti-coagulation therapy eg, warfarin. May reduce the efficacy of OCs.
MIMS Class
ATC Classification
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Augpac FC tab 375 mg
Packing/Price
6's
Form
Augpac FC tab 625 mg
Packing/Price
6's
Form
Augpac Injection powd for inj
Packing/Price
1's
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