Simethicone, Alverine Citrate.
Each softgel capsule contains: Simethicone 300 mg, Alverine Citrate 60 mg.
Excipients/Inactive Ingredients: Silicon dioxide, gelatin, glycerin, purified water, iron oxide yellow, brilliant blue, iron oxide black, titanium dioxide.
Pharmacology: Alverine citrate is a smooth muscle antispasmodic which is approximately 3 times as potent as papaverine and with a longer duration of action. It is neither an anticholinergic nor a derivative of atropine. Its direct spasmolytic action appears to be due to the local anesthetic properties of the drug. It has not been found to block ganglionic or skeletal neuromuscular transmission, nor to significantly reduce gastric or pancreatic secretion.
The clinical use of simethicone is based on its antifoam properties. Silicone antifoams spread on the surface of aqueous liquids, forming a film of low surface tension and thus causing collapse of foam bubbles. Simethicone reportedly allows mucus-surrounded gas bubbles in the GI tract to coalesce and be expelled.
Symptomatic treatment of gastrointestinal disorders such as irritable bowel syndrome or peptic ulcer and that consists of abdominal discomfort (bloating, distention, fullness, pain and/or cramps).
It is also used in the treatment of dysmenorrhea.
Adults: One capsule 1-3 times daily after meals or as directed by physician.
In case of overdosage, please consult the physician.
Hypersensitivity to any components of product.
Patients with intestinal obstruction or paralytic ileus.
Pregnancy & lactation, children under 12 years old.
Should not be recommended when administering to hypotensive patients.
Nausea, headache, pruritus, rash, dizziness and hypotension or temporary lowering of blood pressure have been reported.
Allergic reactions, including anaphylaxis, have also occurred.
Note: Do not use the product if there are any significant changes in appearance of the capsules.
Store below 30°C in a dry place, away from direct sunlight.
Shelf life: Two years from manufacturing date.
A03AX58 - alverine, combinations ; Belongs to the class of other drugs used for functional bowel disorders.
Softgel cap 3 x 10's, 5 x 10's.