Avas

Avas

atorvastatin

Manufacturer:

Micro Labs

Distributor:

Zizawa Healthcare
Concise Prescribing Info
Contents
Atorvastatin
Indications/Uses
As an adjunct to diet to reduce elevated total-C, LDL-C, apo B & triglyceride levels in patients w/ primary hypercholesterolemia (heterozygous familial & nonfamilial) & mixed dyslipidemia (Frederickson types IIa & IIb). Adjunctive therapy to diet for the treatment of patients w/ elevated serum triglycerides (Frederickson type IV). Treatment of patients w/ primary dysbetalipoproteinemia (Frederickson type III) who do not respond adequately to diet. Reduction of total & LDL-C in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering treatments.
Dosage/Direction for Use
Hypercholesterolemia (heterozygous familial & nonfamilial) & mixed dyslipidemia (Frederickson type IIa & IIb) Starting dose: 10 mg daily. Dosage range: 10-80 mg once daily. Homozygous familial hypercholesterolemia 10-80 mg daily.
Administration
May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.
Contraindications
Hypersensitivity. Active liver disease or unexplained persistent elevations of serum transaminase (>3x the ULN). Pregnancy & lactation.
Special Precautions
Perform liver function tests prior to start of treatment & periodically thereafter. Excessive alcohol intake. History of liver disease. Discontinue therapy in acute serious condition suggestive of a myopathy or having a risk factor predisposing to the development of renal failure secondary to rhabdomyolysis. Childn. Elderly.
Adverse Reactions
Constipation, flatulence, dyspepsia, abdominal pain, headache, nausea, myalgia, diarrhoea, asthenia, insomnia.
Drug Interactions
Erythromycin, OC, digoxin, cyclosporine, fibric acid derivatives, azole antifungals or niacin, Mg & Al-containing antacids. Decreased prothrombin time w/ warfarin.
ATC Classification
C10AA05 - atorvastatin ; Belongs to the class of HMG CoA reductase inhibitors. Used in the treatment of hyperlipidemia.
Presentation/Packing
Form
Avas film-coated tab 10 mg
Packing/Price
3 × 10's
Form
Avas film-coated tab 20 mg
Packing/Price
3 × 10's
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