Adverse reactions of prostaglandin analogues and prostamides include brown pigmentation particularly in those with mixed-colour irides, blepharitis, ocular irritation and pain, conjunctival hyperaemia, transient punctate epithelial erosion, skin rash, dry eyes, headache and photophobia; they may also cause, darkening, thickening and lengthening of eye lashes. Less frequent adverse effects include eyelid oedema and rash, keratitis, blurred vision and conjunctivitis. There have been rare reports of dyspnoea, exacerbation of asthma, dizziness, arthralgia, myalgia, iritis. uveitis, local oedema, darkening of palpebral skin. Very rarely chest pain, palpitations and exacerbation of angina has also been reported. Also reported hypotension, bradycardia, browache.