Bacampicillin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Susceptible infections 400-800 mg 2-3 times/day. Uncomplicated gonorrhoea W/ probenecid: 1.6 g as a single dose.
Dosage Details
Oral
Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Meningitis, Otitis media, Perinatal streptococcal infections, Peritonitis, Pneumonia, Septicaemia, Typhoid and paratyphoid fever, Urinary tract infections
Adult: 400-800 mg bid-tid.
Child: >5 yr: 25-50 mg/kg daily in 2-3 divided doses.

Oral
Uncomplicated gonorrhoea
Adult: 1.6 g with 1 g probenecid as a single dose.
Administration
May be taken with or without food. May be taken w/ meals to reduce GI discomfort.
Contraindications
Infectious mononucleosis, lymphatic leukemia, HIV infection; hypersensitivity to penicillins.
Special Precautions
Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitisation may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route. Discontinue in case of skin rash.
Adverse Reactions
Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis. Nausea; vomiting; pseudomembranous colitis.
Drug Interactions
Probenecid prolongs T1/2 of bacampicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
Lab Interference
May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.
Action
Description: Bacampicillin has the antimicrobial action of ampicillin in vivo. It needs to be hydrolysed to ampicillin since it possesses no intrinsic activity.
Pharmacokinetics:
Absorption: Rapidly and absorbed in the GI tract.
Metabolism: Hydrolysed in intestinal walls and plasma to ampicillin.
Excretion: About 75% of a dose is excreted in the urine within 8 hr as ampicillin.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Bacampicillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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