Usual Dose: 250-500 mg with respect to the amoxicillin component every 8 hrs.
Children <10 years: 125-250 mg with respect to the amoxicillin component every 8 hrs; <20 kg bodyweight: 20-40 mg/kg daily in divided doses every 8 hrs.
Neonates and Infants <12 weeks (3 months): Due to incompletely developed renal function affecting elimination of amoxicillin in this age group, the recommended dose is 30 mg/kg/day in divided doses every 12 hrs, based on the amoxicillin component. Clavulanate elimination is unaltered in this age group.
Administration: Amoxicillin with clavulanate potassium may be taken without regard to meals; however, absorption of clavulanate potassium is enhanced when amoxicillin with clavulanate potassium is administered at the start of a meal. To minimize the potential for GI intolerance, amoxicillin with clavulanate potassium should be taken at the start of a meal.