Pharmacological Category: β-lactam antibiotic.
Pharmacology: Mode of Action: The efficacy of amoxicillin with clavulanic acid is the result of bactericidal activity of amoxicillin combined with the inhibitory activity of clavulanic acid on β-lactamases produced by different bacterial strains. Like other β-lactams, clavulanic acid penetrates through the bacterial cell wall but it generally possesses poor intrinsic antimicrobial activity and is generally a more potent inhibitor of cell free β-lactamases. The binding of β-lactamases with clavulanic acid is a complex physiochemical process, which rapidly leads to lysis of the cell.
Pharmacokinetics: Amoxicillin and clavulanate potassium are well absorbed from the gastrointestinal tract (GIT) after oral administration of amoxicillin with clavulanate potassium. The safety and efficacy of amoxicillin with clavulanate potassium have been established in clinical trials where amoxicillin with clavulanate potassium was taken without regard to meals. Amoxicillin diffuses readily into most body tissues and fluids with the exception of the brain and spinal fluid. The results of experiments involving the administration of clavulanic acid to animals suggest that this compound, eg, amoxicillin, is well distributed in body tissues. Approximately 50-70% of the amoxicillin and approximately 25-40% of the clavulanic acid are excreted unchanged in urine during the 1st 6 hrs after oral administration of 500+125 mg of amoxicillin with clavulanate potassium tablets. Concurrent administration of probenecid delays renal excretion of amoxicillin but does not delay renal excretion of clavulanic acid.