The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur (usually involving Pseudomonas or Candida), Bactoclav should be discontinued and/or appropriate therapy instituted. While amoxicillin with clavulanate potassium possesses the characteristic low toxicity of the penicillin group of antibiotics, periodic assessment of organ system functions, including renal, hepatic and hematopoietic function, is advisable during prolonged therapy. A high percentage of patients with mononucleosis who receive ampicillin develop an erythematous skin rash. Thus, ampicillin class antibiotics should not be administered to patients with mononucleosis.
Use in pregnancy & lactation: There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Bactoclav should be used during pregnancy only if clearly needed.
Ampicillin class antibiotics are excreted in the milk; therefore, caution should be exercised when amoxicillin with clavulanate potassium is administered to a nursing woman.