Betamethasone + Clotrimazole


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Topical Tinea cruris; Tinea corporis; Tinea pedis As cream or lotion: Apply onto affected area bid, for up to 2 weeks in tinea cruris and tinea corporis and up to 4 weeks in tinea pedis. Max: 45 g/week.
Dosage Details
Topical/Cutaneous
Tinea corporis, Tinea cruris
Adult: Adult: Available preparation
Each cream or lotion contains betamethasone diproprionate 0.05% and clotrimazole 1%

Apply onto affected area(s) bid, morning and evening, for up to 2 weeks. Max: 45 g /week.
Child: ≥17 yr Same as adult dose.

Topical/Cutaneous
Tinea pedis
Adult: Adult: Available preparation
Each cream or lotion contains betamethasone 0.05% and clotrimazole 1%

Apply onto affected area(s) bid, morning and evening, for up to 4 weeks. Max: 45 g /week.
Child: ≥17 yr Same as adult dose.
Special Precautions
Not recommended for use in diaper dermatitis and under occlusion. Pregnancy and lactation.
Adverse Reactions
Hypercorticism or suppression of hypothalamic-pituitary-adrenal (HPA) axis, Cushing's syndrome, hyperglycaemia, glycosuria; dry skin, burning sensation, paraesthesia, oedema, rash, secondary infection, stinging, skin ulceration.
MonitoringParameters
Monitor for signs of infection and HPA axis suppression.
Action
Description: Betamethasone prevents and reduces inflammation by depressing the migration of polymorphonuclear leukocytes and fibroblasts; reversing capillary permeability and lysosomal stabilisation at the cellular level. Clotrimazole binds to 14-α-demethylation of lanosterol in fungi by binding to 1 of the cytochrome P-450 enzymes leading to the accumulation of 14-α-methylsterols which affects electron transport, and reduced conc of ergosterol which is essential for a normal fungal cytoplasmic membrane, thereby inhibiting growth of fungi.
Pharmacokinetics:
Absorption: Betamethasone: Absorbed through the skin and enters systemic circulation. Clotrimazole: Penetrates the epidermis.
Distribution: Betamethasone: Crosses the placenta.
Metabolism: Undergoes hepatic metabolism. Clotrimazole: Converted to inactive compounds.
Excretion: Betamethasone: Via urine; bile (some amount). Clotrimazole: Via faeces and urine.
Chemical Structure

Chemical Structure Image
Betamethasone

Source: National Center for Biotechnology Information. PubChem Database. Betamethasone, CID=9782, https://pubchem.ncbi.nlm.nih.gov/compound/Betamethasone (accessed on Jan. 21, 2020)


Chemical Structure Image
Clotrimazole

Source: National Center for Biotechnology Information. PubChem Database. Clotrimazole, CID=2812, https://pubchem.ncbi.nlm.nih.gov/compound/Clotrimazole (accessed on Jan. 21, 2020)

Storage
Store between 2-30°C.
References
Anon. Betamethasone and Clotrimazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 14/08/2015.

Buckingham R (ed). Betamethasone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/08/2015.

Buckingham R (ed). Clotrimazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 17/08/2015.

Clotrimazole and Betamethasone Dipropionate Cream (Stat Rx USA). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 17/08/2015.

Derzid-C Cream (Unison Laboratories Co. Ltd). MIMS Myanmar. http://www.mims.com/Myanmar. Accessed 14/08/2015.

McEvoy GK, Snow EK, Miller J et al (eds). Betamethasone, Betamethasone Benzoate, Betamethasone Dipropionate, Betamethasone Valerate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 17/08/2015.

Disclaimer: This information is independently developed by MIMS based on Betamethasone + Clotrimazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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