Betamethasone + Clotrimazole


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Tinea corporis, Tinea cruris
Adult: Available preparations:
Betamethasone dipropionate 0.064% (equivalent to betamethasone 0.05%) and clotrimazole 1% cream
Betamethasone dipropionate 0.064% (equivalent to betamethasone 0.05%) and clotrimazole 1% lotion

Apply thinly onto affected area(s) bid, in the morning and evening, for up to 2 weeks. Max: 45 g per week (as cream); 45 mL per week (as lotion). Reassess the diagnosis if there is no clinical improvement after 1 week.
Child: Available preparations:
Betamethasone dipropionate 0.064% (equivalent to betamethasone 0.05%) and clotrimazole 1% cream
Betamethasone dipropionate 0.064% (equivalent to betamethasone 0.05%) and clotrimazole 1% lotion

≥17 years Same as adult dose. Treatment guidelines may vary among individual products or between countries (refer to local product-specific recommendations).

Topical/Cutaneous
Tinea pedis
Adult: Available preparations:
Betamethasone dipropionate 0.064% (equivalent to betamethasone 0.05%) and clotrimazole 1% cream
Betamethasone dipropionate 0.064% (equivalent to betamethasone 0.05%) and clotrimazole 1% lotion

Apply onto affected area(s) bid, in the morning and evening, for up to 4 weeks. Max: 45 g per week (as cream); 45 mL per week (as lotion). Reassess the diagnosis if there is no clinical improvement after 2 weeks.
Child: Available preparations:
Betamethasone dipropionate 0.064% (equivalent to betamethasone 0.05%) and clotrimazole 1% cream
Betamethasone dipropionate 0.064% (equivalent to betamethasone 0.05%) and clotrimazole 1% lotion

≥17 years Same as adult dose. Treatment guidelines may vary among individual products or between countries (refer to local product-specific recommendations).
Special Precautions
Not recommended for the treatment of diaper dermatitis. Children. Pregnancy and lactation.
Adverse Reactions
Significant: Reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, visual disturbances (e.g. blurred vision, glaucoma, posterior subcapsular cataract, central serous chorioretinopathy); intracranial hypertension, and systemic effects (e.g. manifestations of Cushing’s syndrome, glycosuria, hyperglycaemia) particularly in children.
General disorders and administration site conditions: Oedema.
Infections and infestations: Secondary infection.
Nervous system disorders: Paraesthesia.
Skin and subcutaneous tissue disorders: Burning and stinging sensation, irritation, maculopapular rash, skin dryness, erythema, pruritus, skin peeling, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, skin atrophy, striae, miliaria.
Patient Counseling Information
Do not use occlusive dressing. Avoid contact with eyes or mouth.
Monitoring Parameters
Monitor for signs and symptoms of HPA axis suppression or adrenal insufficiency, signs of skin infection or ocular changes.
Lab Interference
Betamethasone: May suppress the flare and wheal reactions to skin test antigens.
Action
Description: Betamethasone is a corticosteroid that has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces the phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the formation, release, and activity of endogenous chemical mediators of inflammation (e.g. prostaglandins, kinins, histamine, liposomal enzymes).
Clotrimazole is an imidazole antifungal agent. It alters cell wall permeability by binding to phospholipids in the fungal cell membrane which leads to loss of essential intracellular elements, thereby inhibiting fungal growth.
Pharmacokinetics:
Absorption: Betamethasone: Absorbed percutaneously.
Clotrimazole: Penetrates the epidermis.
Distribution: Betamethasone: Crosses the placenta.
Metabolism: Betamethasone: Metabolised in the liver.
Clotrimazole: Metabolised in the liver to inactive compounds.
Excretion: Betamethasone: Via urine and bile.
Clotrimazole: Via faeces and urine.
Chemical Structure

Chemical Structure Image
Betamethasone

Source: National Center for Biotechnology Information. PubChem Database. Betamethasone, CID=9782, https://pubchem.ncbi.nlm.nih.gov/compound/Betamethasone (accessed on Jan. 21, 2020)


Chemical Structure Image
Clotrimazole

Source: National Center for Biotechnology Information. PubChem Database. Clotrimazole, CID=2812, https://pubchem.ncbi.nlm.nih.gov/compound/Clotrimazole (accessed on Jan. 21, 2020)

Storage
Store between 20-25°C.
MIMS Class
Topical Anti-Infectives with Corticosteroids
References
Anon. Betamethasone (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 23/04/2021.

Anon. Betamethasone and Clotrimazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 14/04/2021.

Buckingham R (ed). Betamethasone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/04/2021.

Buckingham R (ed). Clotrimazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/04/2021.

Clotrimazole and Betamethasone Dipropionate Cream (Glenmark Pharmaceuticals Inc. USA). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 14/04/2021.

Clotrimazole and Betamethasone Dipropionate Lotion (Taro Pharmaceuticals U.S.A., Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 14/04/2021.

Creobic DA (Double Action) Cream (Kotra Pharma [M] Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 23/04/2021.

Joint Formulary Committee. Betamethasone with Clotrimazole. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/04/2021.

Lotriderm 0.05% w/w and 1.0% w/w Cream (Organon Pharma [UK] Limited). MHRA. https://products.mhra.gov.uk. Accessed 14/04/2021.

Lotrisone Cream (Merck Sharp & Dohme Corp.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 14/04/2021.

Disclaimer: This information is independently developed by MIMS based on Betamethasone + Clotrimazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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