Generic Medicine Info
Indications and Dosage
Nail fungal infections, Skin fungal infections
Adult: As 1% cream, powder, soln or gel: Apply thinly onto affected areas once daily, preferably at night for 2-4 wk. For nail infections, longer treatment may be necessary; 40% urea paste may be applied initially to soften the nails.
Hypersensitivity to bifonazole.
Special Precautions
Patient w/ history of hypersensitivity reactions to other imidazole antifungals (e.g. econazole, miconazole, clotrimazole). Pregnancy and lactation.
Adverse Reactions
Burning sensation, contact dermatitis, erythema, pruritus, rash, urticaria, blister, skin exfoliation, eczema, dry skin, skin irritation or maceration, peripheral oedema at admin site. Very rarely, systemic hypersensitivity reactions.
Patient Counseling Information
Avoid contact w/ eyes, nose, mouth or other mucous membranes.
Drug Interactions
Possible increase in INR when used w/ warfarin.
Description: Bifonazole is an imidazole derivative w/ broad antifungal spectrum. It inhibits ergosterol synthesis resulting in structural and functional impairment of the fungal cytoplasmic membrane. It also exhibits some antibacterial activity.
Absorption: Absorbed well into infected skin.
Distribution: Penetrates various skin layers including the stratum corneum and stratum papillare.
Excretion: Via urine (45%) and faeces (40%). Elimination half-life: Biphasic: 8 hr and 50 hr.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Bifonazole, CID=2378, (accessed on Jan. 21, 2020)

Store below 30°C.
MIMS Class
Topical Antifungals & Antiparasites
ATC Classification
D01AC10 - bifonazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
Anon. Bifonazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 23/08/2016.

Bayer New Zealand Limited. Canesten Bifonazole Cream data sheet July 2016. Medsafe. Accessed 23/08/2016.

Buckingham R (ed). Bifonazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. Accessed 23/08/2016.

Disclaimer: This information is independently developed by MIMS based on Bifonazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in