Bisoprolol + hydrochlorothiazide - oral

Patient Medicine Information
Why do I need this medicine?
Bisoprolol and Hydrochlorothiazide are combined together in this medicine. This medicine helps keep your blood pressure under control.

Bisoprolol helps your blood pressure to go down by relaxing the blood vessels. Hydrochlorothiazide removes excess water and salts from the body by passing them into the urine. This reduces the amount of water in the body and thus reduces blood pressure.
How do I take this medicine?
Take Bisoprolol + Hydrochlorothiazide exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

Bisoprolol + Hydrochlorothiazide must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed otherwise, as stopping it suddenly could worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • heart disease e.g. severe heart failure, very slow heartbeat, heart block
  • inability to pass urine
as Bisoprolol + Hydrochlorothiazide may not be suitable for you.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • diabetes
  • liver disease
  • blood circulation disorder
  • myasthenia gravis (muscle weakness disorder)
  • phaeochromocytoma (tumour in the adrenal glands)
  • history of mental illness
  • kidney disease
  • systemic lupus erythematosus (an autoimmune disease that causes inflammation)
  • thyroid disease e.g. overactive thyroid
  • chest pain
Let your doctor know if you are pregnant or breastfeeding.

If you are going for surgery or certain laboratory tests, inform your doctor that you are taking Bisoprolol + Hydrochlorothiazide.

For as long as you are taking this medicine, you may need to have regular checking of your blood pressure and heart rate to check your body’s response to the medicine. You may also need to have regular kidney function test and monitoring of your body’s electrolyte levels. Your doctor will advise you how often you need to have them.

What lifestyle changes can I make to improve my blood pressure?

Regular exercise and eating a healthy diet will help lower your blood pressure and improve your overall health. Engage in physical activity (e.g. walking) at least 30 to 60 minutes on most days of the week. If you have not exercised for a long time, start with light exercises such as slow walks. Speak to your doctor about what type of exercise would be suitable for you. Follow a healthy diet plan by eating more fruits, vegetables, whole grains and low-fat dairy products and reduce your intake of foods high in saturated fat, cholesterol and sodium. Cutting down on deep-fried foods and using less salt when cooking can kick-start your healthy diet.

If you smoke, you should try to quit. Smoking is harmful to your blood pressure, heart and overall health. Speak to your doctor or pharmacist about ways to kick your smoking habit.

Try to keep stress levels under control as stress will cause your blood pressure to go up.
What side effects could I experience?
Bisoprolol + Hydrochlorothiazide may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects may include any of the following: headache, nausea, vomiting, diarrhoea, constipation, tiredness and difficulty in sleeping.

This medicine may also cause your skin to be more sensitive to sunlight. Apply sunscreen when going outdoors. Avoid direct or prolonged exposure to the sun and ultraviolet (UV) lamps like tanning beds.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • swollen extremities, face and throat; difficulty swallowing or breathing; rashes
  • chest pain
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor or pharmacist if you are taking any of these medicines:
  • other medicines to help keep blood pressure under control e.g. clonidine, guanethidine, reserpine, diltiazem, verapamil
  • medicines for heart disease e.g. digoxin, disopyramide
  • muscle relaxants e.g. baclofen, tizanidine
  • medicine for mood disorders e.g. lithium, isocarboxazid
  • medicines for diabetes e.g. insulin, glibenclamide, gliclazide, glipizide
  • corticosteroids (anti-inflammatory medicines)
  • adrenocorticotropic hormone, a type of hormone in the body
  • cholesterol-lowering medicines e.g. cholestyramine, colestipol resins
  • medicines for tuberculosis or TB e.g. rifampicin
  • stomach medicines e.g. cimetidine
  • medicines for pain and inflammation (NSAIDs) e.g. aspirin, ibuprofen, indometacin, mefenamic acid
This list does not include all medicines that may interact with Bisoprolol + Hydrochlorothiazide.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on bisoprolol + hydrochlorothiazide - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by
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