Discontinue use if dysphagia, odynophagia, retrosternal pain or new/worsening heartburn develop. Patients w/ active upper GI problems eg, known Barrett's esophagus, dysphagia, other esophageal diseases, gastritis, duodenitis or ulcers. Risk factors for osteonecrosis of the jaw &/or other oro-facial sites including external auditory canal. Esophagitis, esophageal ulcers/erosions; gastric & duodenal ulcers. Treat hypocalcaemia & other disturbances of bone & mineral metabolism prior to treatment. Ensure adequate Ca & vit D intake. Concomitant use w/ NSAIDs. Renal impairment (CrCl <30 mL/min). Not to be used during pregnancy & lactation. Childn <18 yr.