Buclizine


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Motion sickness 25 or 50 mg 30 mins before travelling, repeat after 4-6 hr if needed. Migraine 12.5 mg at the start of an attack. Alleviation of nausea 25 or 50 mg/day, up to 150 mg/day in severe cases. Pruritic skin disorders 25-50 mg/day.
Dosage Details
Oral
Prophylaxis of motion sickness
Adult: As hydrochloride: 25 or 50 mg given 30 min before travelling, repeated after 4-6 hr, if necessary.

Oral
Pruritic skin disorders
Adult: As hydrochloride: 25-50 mg daily.

Oral
Nausea and vomiting
Adult: As hydrochloride: 25 or 50 mg tid.

Oral
Migraine
Adult: As hydrochloride: 12.5 mg taken as soon as symptoms arise.
Child: 10-14 yr: 6.25 mg at the start of the symptoms. >14 yr: follow adult dose.
Administration
Should be taken with food. Take w/in 30 min before meals.
Contraindications
Hypersensitivity; neonates.
Special Precautions
Driving or operating machinery; open-angle glaucoma; urinary retention; prostatic hyperplasia, pyloroduodenal obstruction, epilepsy; renal and hepatic impairment; pregnancy.
Adverse Reactions
Drowsiness, dizziness, incoordination; blurred vision; urinary retention; vomiting; rash; dry mouth; headache, nausea, epigastric pain, wt gain and diarrhoea.
Drug Interactions
Potentially Fatal: Effect of alcohol, sedatives and other CNS depressants potentiated.
Action
Description: Buclizine is a piperazine antihistamine with antimuscarinic and moderate sedative properties. It is used mainly for its antiemetic action and in the treatment of migraine in combination with analgesics.
Disclaimer: This information is independently developed by MIMS based on Buclizine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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