Carbenicillin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO UTI 382-764 mg 6 hrly. Prostatitis 764 mg 6 hrly.
Dosage Details
Oral
Prostatitis
Adult: 764 mg every 6 hr.

Oral
Urinary tract infections
Adult: 382-764 mg every 6 hr.
Renal Impairment
CrClDosage
<10Not recommended.
10-50382-764 mg every 12-24 hr.
Administration
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals.
Contraindications
Hypersensitivity.
Special Precautions
Restricted sodium diet. Severely impaired renal function or heart failure. Avoid contact, skin sensitisation may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route.
Adverse Reactions
Pain at inj site and phloebitis; electrolyte disturbances; dose-dependent coagulation defect; purpura and haemorrhage; hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis.
Potentially Fatal: Anaphylaxis.
Drug Interactions
Probenecid prolongs T1/2 of carbenicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.
Lab Interference
May interfere with diagnostic tests for urinary glucose using copper sulfate, direct Coomb's test, and test for urinary or serum proteins. May interfere with diagnostic tests that use bacteria.
Action
Description: Carbenicillin has an extended spectrum of activity against gm-ve bacteria. It is used in the treatment of infections caused by P. aeruginosa and non-penicillinase-producing strains of Proteus spp. Antimicrobial activity can be enhanced by aminoglycosides. It inhibits final cross-linking stage of peptidoglycan production by binding and inactivating transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis.
Pharmacokinetics:
Absorption: Not absorbed from GI tract.
Distribution: 50% bound to plasma proteins.
Excretion: half-life about 1-1.5 hr, increased in renal impairment. Excreted mainly by renal tubular secrettion and glomerular filtration.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Carbenicillin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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