Carboprost


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : IM Pregnancy termination in the 2nd trimester Initial: 250 mcg. Alternatively, initiate w/ test dose of 100 mcg. May be repeated at 1.5- to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if uterine contractility is inadequate. Max: 12 mg. Max duration: 2 days. Postpartum haemorrhage Initial: 250 mcg. May be repeated every 15-90-min. Max: 2 mg.
Dosage Details
Intramuscular
Pregnancy termination in the 2nd trimester
Adult: Initially, 250 mcg. Alternatively, initiate w/ test dose of 100 mcg. May be repeated at 1.5- to 3.5-hr intervals depending on uterine response. May be increased to 500 mcg if uterine contractility is inadequate. Max: 12 mg. Max duration: 2 days.

Intramuscular
Postpartum haemorrhage
Adult: Initially, 250 mcg by deep inj. May be repeated every 15-90-min. Max: 2 mg.
Contraindications
Acute pelvic inflammatory disease; active cardiac, pulmonary, renal or hepatic disease.
Special Precautions
Patient w/ compromised (scarred) uteri; history of asthma, seizure disorders, DM, anaemia, glaucoma or raised intra-ocular pressure, HTN, hypotension, CV disease, hepatic disease, including jaundice or renal disease. Pregnancy and lactation.
Adverse Reactions
Vomiting, diarrhoea, nausea, transient fever, flushing, increased BP, bronchospasm, dyspnoea, pulmonary oedema.
IM/Parenteral: C
Patient Counseling Information
This drug may cause syncope, dizziness and somnolence, if affected, do not drive or use machines.
MonitoringParameters
Monitor for reductions in arterial-oxygen content in patients w/ cardiopulmonary disorders.
Overdosage
Symptoms: HTN, increased body temp. Management: Symptomatic treatment.
Drug Interactions
May potentiate effect of other oxytocics.
Action
Description: Carboprost, a synthetic analogue of naturally occurring prostaglandin F, stimulates uterine contractility, resulting in expulsion of the products of conception. It is also used to induce abortion between 13-20 wk of pregnancy. It produces myometrial contractions responsible for placental haemostasis.
Onset: Postpartum haemorrhage: Approx 45 min (increase in uterine tone and decreased bleeding).
Pharmacokinetics:
Absorption: Rapidly absorbed following IM admin. Time to peak plasma concentration: 20-30 min.
Distribution: Crosses the placenta.
Metabolism: Undergoes metabolism via omega-oxidation.
Excretion: Via urine (83%) mainly as metabolites.
Chemical Structure

Chemical Structure Image
Carboprost

Source: National Center for Biotechnology Information. PubChem Database. Carboprost tromethamine, CID=5281074, https://pubchem.ncbi.nlm.nih.gov/compound/Carboprost-tromethamine (accessed on Jan. 21, 2020)

Storage
Store between 2-8°C.
ATC Classification
G02AD04 - carboprost ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
Disclaimer: This information is independently developed by MIMS based on Carboprost from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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