May enhance the nephrotoxic effect of aminoglycosides. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. Concomitant use w/ warfarin may increase prothrombin time. Probenecid inhibits renal excretion of cefaclor.
Food may delay the rate but does not affect the extent of absorption.
False-positive reaction in urinary glucose test using Benedict's or Fehling's soln or copper sulfate test tablets. Positive direct Coombs' test.
Description: Cefaclor inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Pharmacokinetics: Absorption: Well absorbed from the GI tract. Food may delay the rate but does not affect the extent of absorption. Time to peak plasma concentration: 0.5-1 hr. Distribution: Widely distributed. Crosses the placenta and enters breast milk. Plasma protein binding: Approx 25%. Excretion: Via urine (up to 85%, as unchanged drug). Plasma half-life: 0.5-1 hr.
Store between 20-25°C. Protect from moisture. Reconstituted powd for susp: Store between 2-8°C.
J01DC04 - cefaclor ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Anon. Cefaclor. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/10/2014.Buckingham R (ed). Cefaclor. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/10/2014.Cefaclor Capsule (Carlsbad Technology, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/10/2014.Cefaclor Suspension (Carlsbad Technology Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/10/2014.McEvoy GK, Snow EK, Miller J et al (eds). Cefaclor. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 10/10/2014.