Celiprolol


Concise Prescribing Info
Indications/Uses
HTN.
Dosage/Direction for Use
Adult : PO 200-400 mg once daily.
Dosage Details
Oral
Hypertension
Adult: 200-400 mg once daily.
Renal Impairment
CrCl Dosage
<15 Avoid.
15-40 100-200 mg/day.
Administration
Should be taken on an empty stomach. Take at least 30 min before or 2 hr after meals.
Contraindications
Heart block (2nd or 3rd degree), sick-sinus syndrome, cardiogenic shock, uncontrolled heart failure, severe bradycardia, severe renal impairment (CrCl <15 mL/min), acute episodes of asthma, untreated phaeochromocytoma, metabolic acidosis, hypotension, or severe peripheral arterial circulatory disturbances.
Special Precautions
Patients w/ 1st degree heart block, well-controlled CHF, DM, untreated phaeochromocytoma, history of psoriasis. Avoid abrupt withdrawal as it may increase the risk of angina. Patients undergoing surgery involving general anaesth. May mask symptoms of hypoglycaemia and thyrotoxicosishyperthyroidism. Hepatic and mild to moderate renal impairment. Pregnancy and lactation.
Adverse Reactions
Headache, fatigue, dizziness, hot flushes, asthenia, somnolence and insomnia; tremor and palpitations; bronchospasm, skin rashes and/or visual disturbances. Rarely, depression, hypersensitivity, pneumonitis.
MonitoringParameters
Monitor BP and ECG.
Drug Interactions
May exacerbate rebound HTN upon withdrawal of clonidine. May increase AV conduction time w/ digitalis glycosides. Reduced bioavailability w/ concomitant hydrochlorothiazide, chlorthalidone or theophylline. Concomitant dihydropyridine Ca channel blockers (e.g. nifedipine) may increase the risk of hypotension and heart failure.
Lab Interference
May cause false-positive result in drug screening test.
Action
Description: Celiprolol is a cardioselective β-blocker. It exhibits intrinsic sympathomimetic and direct vasodilator activity.
Pharmacokinetics:
Absorption: Incompletely absorbed from the GI tract. Food may impair its bioavailability.
Distribution: Crosses the placenta. Plasma protein binding: Approx 25%.
Metabolism: Minimal metabolism.
Excretion: Via urine and faeces (as unchanged drug). Elimination half-life: Approx 5-6 hr.
Storage
Store below 25°C.
MIMS Class
References
Anon. Celiprolol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/12/2013.

Buckingham R (ed). Celiprolol HCl. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/12/2013.

Joint Formulary Committee. Celiprolol HCl. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/12/2013.

Disclaimer: This information is independently developed by MIMS based on Celiprolol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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