CERAZONE PLUS-500 should be administered cautiously to penicillin sensitive patients due to the possibility of developing hypersensitivity reactions. Pseudomembranous colitis has been reported with the use of Cephalosporins and other broad spectrum antibiotics. This is because treatment with broad-spectrum antibiotics alters the normal flora of the colon and may permit overgrowth of Clostridia. Studies indicate that a toxin produced by Clostridium difficile is the primary cause of antibiotic-associated colitis or diarrhea. Mild cases of colitis may respond to drug discontinuance alone. Moderate to severe cases should be managed with fluid, electrolyte, and protein supplementation as indicated.