Chlortetracycline


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Ophth Ocular infections As 1% oint: Apply 1 cm to the conjunctiva 2-4 hrly. Topical Minor skin infections As 3% oint: Apply 1-2 times/day.
Dosage Details
Ophthalmic
Ocular infections
Adult: Apply thin strip (approximately 1 cm) of 1% oint to the conjunctiva every 2-4 hrs or more frequently.
Child: Same as adult dose.

Topical/Cutaneous
Minor skin infections
Adult: Apply 3% oint to affected area 1-2 times/day.
Child: Same as adult dose.
Contraindications
Hypersensitivity; systemic lupus erythematosus; severe renal impairment; pregnancy, lactation; child ≤12 yrs.
Special Precautions
Myasthenia gravis; avoid direct sunlight; elderly; hepatic impairment.
Adverse Reactions
Hypersensitivity and photosensitivity reactions; abnormal pigmentation of the eye; myopia.
Drug Interactions
Preparations containing divalent and trivalent cations; Na bicarbonate, colestipol; kaolin-pectin; potentially hepatotoxic drugs; diuretics, methoxyflurane; other potentially nephrotoxic drugs; oral anticoagulants; atovaquone; thiomersal (ocular inflammation); OC (decrease effect); retinoids (increased risk of benign intracranial hypertension).
Potentially Fatal: Increased toxic effects of ergot alkaloids and methotrexate.
Food Interaction
Dairy and milk products.
Lab Interference
May interfere with determination of urinary catecholamines or glucose. Increase in liver enzyme values.
Action
Description: Chlortetracycline prevents the binding of aminoacyl transfer RNA, thus inhibiting protein synthesis and cell growth. It has a broad spectrum of antimicrobial activity which includes chlamydias, rickettsias, spirochetes, many aerobic and anaerobic gm-ve and gm+ve pathogenic bacteria and some protozoa.
Disclaimer: This information is independently developed by MIMS based on Chlortetracycline from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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