Chorionic gonadotrophin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : IM Male infertility due to hypogonadotrophic hypogonadism 500-1,000 units 2-3 times/wk. Delayed puberty due to hypogonadism in males 1,500 units twice wkly for at least 6 mth. Anovulatory infertility 5,000-10,000 u as a single dose. May repeat inj (up to 5,000 u/inj) up to 3 times w/in the next 9 days.
Dosage Details
Intramuscular
Delayed puberty associated with hypogonadism in males
Adult: Male: 1,500 units twice weekly for at least 6 months.

Intramuscular
Male infertility due to hypogonadotrophic hypogonadism
Adult: 500-1,000 units 2-3 times weekly.

Intramuscular
Anovulatory infertility
Adult: Single dose of 5000-10,000 u. Up to 3 repeated injections of up to 5000 u each may be given within the following 9 days to prevent corpus luteum insufficiency.
Contraindications
Hypersensitivity; precocious puberty, prostatic carcinoma or other androgenic dependent neoplasm. Pregnancy and lactation.
Special Precautions
Discontinue therapy if signs of precocious puberty are seen in patients treated for cryptorchidism. Patients with cardiac or renal disease, epilepsy, migraine or asthma.
Adverse Reactions
Headache, irritability, restlessness, depression, fatigue, oedema; precocious puberty, gynaecomastia; pain at Inj site; enlargement of preexisting ovarian cysts and possible rupture; arterial thromboembolism; shock; abdominal pain.
Potentially Fatal: Ovarian hyperstimulation syndrome (OHSS).
IM/Parenteral/SC: X
Action
Description: Chorionic Gonadotrophin is a polypeptide hormone produced by the human placenta. It stimulates the production of gonadal steroid hormones by inducing interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone.
Pharmacokinetics:
Absorption: Peak concentrations after 6 hrs (IM).
Distribution: Mainly in the gonads.
Excretion: Via the urine (10-12% of IM dose within 24 hrs). Elimination half-life: 6-11 hrs (initial phase), 23-38 hrs (terminal phase).
Storage
Store at 15-30°C.
Disclaimer: This information is independently developed by MIMS based on Chorionic gonadotrophin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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