Citric acid


Concise Prescribing Info
Indications/Uses
As an alkaliniser agent.
Dosage/Direction for Use
Adult : PO As Na citrate and citric acid soln: 10-30 mL after meals and at bedtime. As Na citrate: 1-2 g 2-4 hrly when needed.
Dosage Details
Oral
Alkaliniser agent
Adult: As sodium citrate and citric acid solution: 10-30 ml after meals and at bedtime. Dosage should be individualised according to patient's response and tolerance. As sodium citrate: 1-2 g every 2-4 hr when necessary.
Child: As sodium citrate and citric acid solution: 5-15 ml after meals and at bedtime. Dosage should be individualised according to patient's response and tolerance.
Contraindications
Patients on a sodium-restricted diet. Severe renal impairment. Potassium citrate and citric acid oral solution are contraindicated in patients with adynamia episodica hereditaria, acute dehydration, heat cramps, anuria, severe myocardial damage, or hyperkalaemia.
Special Precautions
Monitor electrolyte balance and acid-base balance regularly especially in patients with renal disorders. Patients with low urine output, congestive heart failure, hypertension, renal dysfunction, peripheral or pulmonary oedema, or toxaemia of pregnancy. Preparations containing potassium should be used with extreme caution in patients in whom large amount of potassium may have a detrimental effect.
Adverse Reactions
Frequent administration or intake of large quantities may cause teeth erosion and have a local irritant effect.
Drug Interactions
Oral doses of citrate may increase intestinal absorption of aluminium ions.
Action
Description: Citrate salts are alkalinisers. They are commonly used in situations where long-term maintenance of an alkaline urine is necessary and in the management of chronic metabolic acidosis. Citric acid is also used in effervescing mixtures and as a synergist to improve the efficacy of antioxidants. It may also be used in preparations that are used in the treatment of dry mouth and to dissolve renal calculi and prevent encrustation of urinary catheters.
Pharmacokinetics:
Metabolism: Citrate salts are largely metabolised.
Excretion: <5% of an oral dose is excreted unchanged in the urine.
Disclaimer: This information is independently developed by MIMS based on Citric acid from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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