Individualized dosage.
HTN Initially 5 mg once daily in the morning, may be increased to 10 mg once daily after 1 mth.
Patient w/ strongly activated renin-angiotensin-aldosterone system (RAAS) Initially 2.5 mg.
Patient in concomitant use w/ diuretics that cannot be discontinued Initially 2.5 mg, monitor renal function & serum K levels.
Elderly Initially 2.5 mg, may be increased to 5 mg after 1 mth, then to 10 mg if necessary depending on renal function.
Stable CAD Initially 5 mg once daily for 2 wk, then increased to 10 mg once daily if well tolerated, depending on renal function.
Elderly 2.5 mg once daily for 1 wk, then 5 mg once daily on the following wk, then increased up to 10 mg once daily, depending on renal function.
Symptomatic heart failure Initially 2.5 mg in the morning, may be increased to 5 mg once daily after 2 wk if tolerated.
Renal impairment: CrCl ≥60 mL/min 5 mg daily,
30-60 mL/min 2.5 mg daily,
15-30 mL/min 2.5 mg every other day,
<15 mL/min 2.5 mg on the day of dialysis (take dose after dialysis in haemodialysis patients).