Cromoglicic acid


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Food allergy; Mastocytosis 200 mg 4 times/day, may double dose if effect unsatisfactory by 2-3 wk. Max: 40 mg/kg/day. Inhalation Asthma prophylaxis As dry powd/ nebulising soln: 20 mg 4 times/day or as aerosol:10 mg 4 times/day, up to 6-8 times/day if needed, reduced to 5 mg 4 times/day once asthma has stabilised. Additional doses may be taken before exercise. Ophth Allergic conjunctivitis As 4% soln: Instill 2 drops 4-6 times/day. As 4% oint: Apply 2-3 times/day. Nasal Allergic rhinitis As 2 or 4% soln/spray: 2.5 or 5 mg 4 times/day.
Dosage Details
Inhalation/Respiratory
Asthma prophylaxis
Adult: 20 mg four times daily as dry powder/nebulised soln or 10 mg four times daily as aerosol, increased to 6-8 times daily if necessary, reduced to 5 mg four times daily once asthma has been stabilised. Additional doses may be taken before exercise.

Nasal
Allergic rhinitis
Adult: 2.5 or 5 mg of a 2% or 4% soln is admin as drops or spray into each nostril 4 times daily.

Ophthalmic
Allergic conjunctivitis
Adult: Instill 2 drops of a 4% soln 4-6 times daily or apply a 4% oint bid-tid.

Oral
Food allergy, Mastocytosis
Adult: 200 mg four times daily. May double the dose if effect is not satisfactory within 2-3 wk. Max: 40 mg/kg/day.
Child: 100 mg four times daily. May double the dose if effect is not satisfactory within 2-3 weeks.
Renal Impairment
Dosage adjustment may be needed.
Hepatic Impairment
Dosage adjustment may be needed.
Contraindications
Hypersensitivity.
Special Precautions
Lactation, cardiac arrhythmias, hepatic or renal dysfunction.
Adverse Reactions
Nausea, headache, dizziness, unpleasant taste, joint pain and swelling, skin rashes, aggravation of asthma, pulmonary infiltrates with eosinophilia, urticaria. Bronchospasm, wheezing, cough, nasal congestion and throat irritation following inhalation of dry powder. Intranasal use: Transient irritation of nasal mucosa. Sneezing and epistaxis (occasional). Eye drops: Transient burning and stinging.
Action
Description: Cromoglycic acid inhibits degranulation of mast cells and therefore suppresses the release of histamine, leukotrienes and slow-reacting substance of anaphylaxis.
Pharmacokinetics:
Absorption: Oral: Poorly absorbed from the GIT with only 1% bioavailability. Inhalation: 8-10% of a dose of fine powd is deposited and rapidly absorbed from the lungs. Intranasal: < 7% of the dose is absorbed. Ophthalmic: 0.03% is absorbed.
Storage
Store at 25°C.
Disclaimer: This information is independently developed by MIMS based on Cromoglicic acid from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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