amoxicillin + clavulanic acid






Mega Lifesciences
Concise Prescribing Info
Co-amoxiclav (amoxicillin & clavulanic acid). Per 625 mg FC tab Amoxicillin 500 mg, clavulanic acid 125 mg. Per 156.25 mg/5 mL oral susp Amoxicillin 125 mg, clavulanic acid 31.25 mg. Per 312.5 mg/5 mL oral susp Amoxicillin 250 mg, clavulanic acid 62.5 mg
Upper resp tract infections (including ear, nose & throat); skin & soft tissue infections; lower resp tract infections; GUT infections; osteomyelitis, septicaemia, peritonitis & post-op infections.
Dosage/Direction for Use
Tab Adult & childn >12 yr Mild to moderate infections 375 mg tds. More severe, & resp tract infections 625 mg tds. Childn <12 yr Based on 25-50 mg/kg/day (based on amoxycillin component), depending on the severity of infection. Oral susp Childn 7-12 yr 10 mL of susp 156.25 mg/5 mL tds or 5 mL of susp 312.5 mg/5 mL tds; 2-7 yr 5 mL of susp 156.25 mg/5 mL tds; 9 mth-2 yr 2.5 mL of susp 156.25 mg/5 mL tds. Moderate impairment (CrCl 10-30 mL/min) 375 or 625 mg 12 hrly. Severe impairment (CrCl <10 mL/min) 375 mg 12 hrly, or 625 mg 24 hrly.
Should be taken with food. Film-coated tab: Swallow whole w/ water.
Hypersensitivity to penicillins. Potential cross-allergy w/ other penicillin derivatives & cephalosporins. Not for patients w/ infectious mononucleosis or lymphatic leukemia. Antiperistaltics.
Special Precautions
Do not exceed treatment to 14 days w/o review. Discontinue w/ antibiotic-induced pseudomonas colitis w/ severe & persistent diarrhea. Carry out dark field exam in patients w/ gonorrhoea & suspected primary syphilitic lesions. Patients w/ allergic diathesis, bronchial asthma, urticaria or hay fever. Renal & hepatic insufficiency. Pregnancy & lactation.
Adverse Reactions
Diarrhoea, nausea, vomiting & digestive disturbances. Skin rash, pruritus, urticaria, fever & joint pain; angioneurotic oedema, anaphylaxis, erythema multiforme exudativum, Stevens-Johnson syndrome & exfoliative dermatitis. Leukopenia, thrombocytopenia, agranulocytosis & eosinophilia. Changes of hepatic function parameters (SGOT & SGPT); transient hepatitis & cholestatic jaundice.
Drug Interactions
Antiperistaltics. Potential occurrence of cutaneous reactions w/ allopurinol. May attenuate effects of OCs. False +ve results w/ non-enzymatic methods for determination of urinary sugar. Urobilinogen tests can be affected & may result to +ve direct antiglobilin tests. Avoid alcohol intake for potential antabuse-like syndrome. Do not administer concomitantly w/ disulfiram. Amoxycillin: Prolonged increased conc w/ probenecid. Reduced absorption w/ antacids.
MIMS Class
ATC Classification
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Curam FC tab 625 mg
3 × 5's
Curam powd for oral susp 156.25 mg/5 mL
100 mL x 1's
Curam powd for oral susp 312.5 mg/5 mL
100 mL x 1's
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