Daflon 500 mg

Daflon 500 mg Mechanism of Action

diosmin + hesperidin




Full Prescribing Info
Daflon 500 mg is a phlebotonic drug and a vascular protecting agent.
The efficacy of Daflon 500 mg is accounted for by its specific action on the principal elements of venous disease.
Daflon 500 mg is phlebotonic: It reinforces venous tone by prolonging the activity of parietal noradrenaline with a more rapid onset and longer duration compared to placebo. Thus, Daflon 500 mg decreases venous capacitance, venous distensibility and venous emptying time.
Daflon 500 mg protects the microcirculation by fighting the microcirculation-damaging process; it combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandins. Thus, Daflon 500 mg normalizes capillary permeability and strengthens capillary resistance.
Daflon 500 mg acts on the lymphatic system: It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure. This action on the lymphatic system associated with a phlebotonic and vasculoprotective effect, explains the activity of Daflon 500 mg on CVI-associated edema.
Double-blind, placebo-controlled studies have demonstrated Daflon 500 mg's efficacy on chronic venous insufficiency. Daflon 500 mg significantly improves disabling symptoms of venous insufficiency which affect everyday active life: Heavy legs, pain, heat sensation, edema, functional impairment and nocturnal cramps.
In addition to conventional compression therapy, Daflon 500 mg has also demonstrated to cure 3 times as many venous leg ulcers as placebo, and to accelerate their complete healing.
Daflon 500 mg is highly effective in the treatment of chronic hemorrhoidal disease. It significantly improves subjective symptoms and objective signs eg, anal discomfort, pain, redness, anal discharge, proctitis, tenesmus, pruritus, erythema and bleeding. Daflon 500 mg also significantly reduces the frequency, severity and duration of acute hemorrhoidal attacks and bleeding by chronic treatment.
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