Daratumumab - intravenous


Patient Medicine Information
Why do I need this medicine?
Daratumumab is used on its own or together with other medicines to treat multiple myeloma (cancer of the bone marrow).
How do I use this medicine?
Daratumumab injection is to be given intravenously (into the vein). It is delivered directly into the bloodstream via the blood vessel.

Your doctor or nurse will administer the injection for you.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your condition.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Daratumumab.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
When should I not use this medicine?
Do not use Daratumumab if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • severe, recurring or at risk of infections
  • hepatitis B (contagious liver infection caused by a virus from contaminated blood and body fluids)
Let your doctor know if you are pregnant or breastfeeding.

It is important that you do not get pregnant while being treated with Daratumumab. You must use effective contraception during and for 3 months after treatment. You may wish to discuss birth control methods with your doctor or pharmacist.

This medicine may interfere with certain tests for antiglobulin. Inform your doctor that you are using this medicine before undergoing laboratory tests.

For as long as you are using this medicine, you may need to have regular blood tests to check your body’s response to the medicine. Your doctor will advise you about how often you need to have blood tests.
What side effects could I experience?
Daratumumab may cause fatigue. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: diarrhoea, constipation, nausea, vomiting, back pain, headache, pain in arms or legs, joint pain, loss of appetite, tingling or numbness in the hands and feet, and swelling in the arms or legs.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swelling of the face, eyes or mouth
  • fever, chills
  • shortness of breath or difficulty breathing
  • changes in skin colour
  • throat tightness
This medicine may cause the level of your red blood cells, white blood cells and platelets to drop.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Inform your doctor if you have a fever, or a cough or flu that does not go away.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Inform your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store between 2-8°C. Do not allow to freeze. If frozen, this medicine will become ineffective and should not be used.

Do not shake. Protect from light.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on daratumumab - intravenous and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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