Deserpidine


Concise Prescribing Info
Contraindications
Patients receiving electroconvulsive therapy, depression or a history of depression, active peptic ulcer or ulcerative colitis, Parkinson's disease.
Special Precautions
Debilitated or elderly patients, cardiac arrhythmias, MI, renal insufficiency, gallstones, epilepsy, allergic conditions, pheochromocytoma.
Adverse Reactions
Nasal congestion, headache, CNS symptoms, GI disturbances. resp distress, cyanosis, anorexia and lethargy may occur in infants whose mothers have received deserpidine prior to delivery. At higher doses, flushing, bradycardia, severe depression, extrapyramidal effects, breast engorgement, galactorrhoea, gynaecomastia, increased prolactin concentrations, decreased libido, impotence, Na retention, oedema, decreased or increased appetite, wt gain, miosis, dry mouth, sialorrhoea, dysuria, rashes, pruritus, thrombocytopaenic purpura.
Drug Interactions
Adrenaline, sympathomimetics, thiazide diuretics, other antihypertensives, MAOIs, digitalis or quinidine, CNS depressants.
Action
Description: Deserpidine causes depletion of noradrenaline stores in peripheral sympathetic nerve terminals and depletion of catecholamine and serotonin stores in the brain, heart, and many other organs resulting in a reduction in BP, bradycardia and CNS depression. The hypotensive effect is mainly due to a reduction in cardiac output and peripheral resistance. CV reflexes are partially inhibited, but postural hypotension is rarely a problem. It is used in the treatment of hypertension and psychoses.
Disclaimer: This information is independently developed by MIMS based on Deserpidine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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