Desoximetasone


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : Topical Corticosteroid-responsive dermatoses As 0.05-0.25% cream/gel/lotion/oint: Apply to affected area bid. Plaque psoriasis As 0.25% spray: Apply to affected area bid.
Dosage Details
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05-0.25% cream/gel/lotion/oint: Apply a thin film onto affected area bid. Rub in gently.
Child: Same as adult dose.

Topical/Cutaneous
Plaque psoriasis
Adult: As 0.25% spray: Apply a thin film onto affected area bid. Rub in gently.
Special Precautions
Childn. Pregnancy and lactation.
Adverse Reactions
Atrophy, striae, telangiectasias, burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentations, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, miliaria. Reversible HPA axis suppression, Cushing’s syndrome, hyperglycaemia, unmasking of latent DM (from systemic absorption).
Patient Counseling Information
Avoid use of occlusive dressings. Topical spray is flammable, avoid exposure to heat and flame or smoking during or immediately after application.
MonitoringParameters
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression through ACTH stimulation or urinary free cortisol test.
Drug Interactions
May diminish the antineoplastic effect of aldesleukin. May potentiate the hyperglycaemic effect of ceritinib. May diminish the therapeutic effect of corticorelin and hyaluronidase. May enhance the adverse/toxic effects of deferasirox.
Action
Description: Desoximetasone is a topical corticosteroid that induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid hence depresses the formation, release, and activity of endogenous chemical mediators such as kinins, histamine, liposomal enzymes, and prostaglandins.
Pharmacokinetics:
Absorption: Absorbed through normal skin; increased percutaneous absorption in traumatised or inflamed skin.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Desoximetasone, CID=5311067, https://pubchem.ncbi.nlm.nih.gov/compound/Desoximetasone (accessed on Jan. 20, 2020)

Storage
Store between 20-25°C. Spray: Protect from heat or flame.
ATC Classification
D07AC03 - desoximetasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.
References
Anon. Desoximetasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 23/11/2016.

Buckingham R (ed). Desoximetasone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 23/11/2016.

Desoximetasone Cream (Perrigo New York Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2016.

Desoximetasone Ointment (Teligent Pharma, Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Desoximetasone (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 23/11/2016.

Topicort Ointment USP 0.05% (Taro Pharmaceuticals Inc) . U.S. FDA. https://www.fda.gov/. Accessed 23/11/2016.

Topicort Spray (Taro Pharmaceuticals U.S.A., Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2016.

Disclaimer: This information is independently developed by MIMS based on Desoximetasone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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