Diazon

Diazon

ketoconazole

Manufacturer:

Unison

Distributor:

R. Oasis
Concise Prescribing Info
Contents
Ketoconazole
Indications/Uses
Esophageal & oropharyngeal candidiasis; disseminated candidiasis including peritonitis, pneumonia & UTI; severe, chronic extensive mucocutaneous candidiasis; chromomycosis; paracoccidioidomycosis caused by Paracoccidioides brasiliensis; pityriasis versicolor, tinea corporis, tinea cruris, & tinea pedis infections.
Dosage/Direction for Use
Pityriasis versicolor Adult & adolescent 200 mg once daily for 5-10 days. Max: 1 g daily. Other antifungal indications Adult & adolescent 200-400 mg once daily. Max: 1 g daily. Childn ≥2 yr 3.3-6.6 mg/kg once daily.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to azole antifungals. Consider risk-benefit: achlorhydria or hypochlorhydria; active or in remission alcoholism; hepatic impairment.
Special Precautions
Pregnancy & lactation. Childn <2 yr.
Adverse Reactions
Fever & chills, skin rash or itching; dizziness, drowsiness, headache; abdominal pain, constipation, diarrhea, loss of appetite, nausea, vomiting; gynecomastia, impotence, menstrual irregularities; photophobia.
Drug Interactions
May increase incidence of hepatotoxicity w/ other hepatotoxic medications. Concurrent ingestion of alcohol may result in disulfiram-like reactions. Concurrent use elevates plasma conc of oral midazolam or triazolam; astemizole or terfenadine; cisapride; ciclosporin & tacrolimus. May reduce absorption w/ antacids or anticholinergics/antispasmodic, histamine H2-receptor antagonists or omeprazole & sucralfate; didanosine. May increase serum digoxin conc. Increases AUC of indinavir. May increase metabolism by rifampicin. Decrease serum conc w/ INH. May increase anticoagulant effects w/ warfarin.
MIMS Class
ATC Classification
J02AB02 - ketoconazole ; Belongs to the class of imidazole derivatives. Used in the systemic treatment of mycotic infections.
Presentation/Packing
Form
Diazon tab 200 mg
Packing/Price
10 × 10's
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