Docusates


Concise Prescribing Info
Indications/Uses
Constipation.
Dosage/Direction for Use
Adult : POAs Ca: 240 mg/day. As Na: 50-300 mg/day in divided doses, up to 500 mg/day. Rectal 120-200 mg as an enema.
Dosage Details
Oral
Constipation
Adult: As calcium: 240 mg. As sodium: 50-300 mg daily in divided doses, increased up to 500 mg daily.
Child: 120 mg daily.

Rectal
Constipation
Adult: 120-200 mg given as an enema.
Contraindications
Hypersensitivity; intestinal obstruction, undiagnosed abdominal pain; prolonged use. It should not be used to soften earwax when there is inflammation and/or eardrum perforation.
Special Precautions
Pregnancy, lactation, neonates; do not give with liqd paraffin; rectal prep not to be given if haemorrhoids or anal fissure present.
Adverse Reactions
Diarrhoea, nausea, abdominal cramps, skin rash. Rectal: Anorectal pain or bleeding.
Drug Interactions
Potentially Fatal: It may facilitate the GI absorption or hepatic cell uptake of other drugs, enhancing their activity and possibly increasing their toxicity. Concomitant admin wtih aspirin increases adverse effects on GI mucosa.
Action
Description: Docusates are faecal softeners used mainly in the treatment of constipation. These anionic surfactants are considered to act primarily by increasing the penetration of fluid into the faeces.
Onset: 12-72 hr.
Pharmacokinetics:
Absorption: Absorbed from the GI tract (oral).
Distribution: Enters breast milk (as sodium).
Excretion: Faeces
Storage
Store at 15-30°C.
Disclaimer: This information is independently developed by MIMS based on Docusates from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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