Salbutamol sulfate should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias and hypertension; in patients with convulsive disorders, hyperthyroidism or diabetes mellitus; and in patients who are unusually responsive to sympathomimetic amines.
Use in pregnancy & lactation: Salbutamol has been demonstrated to be teratogenic in mice.
It is not known whether salbutamol sulfate is excreted in human milk. Because of the potential for tumorigenicity shown for salbutamol sulfate in animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Use in children: Safety and effectiveness in children <6 years have not been established.