Durasalyn-CR Drug Interactions


Raptakos, Brett


Full Prescribing Info
Drug Interactions
The following drug interactions have been demonstrated with theophylline. Agents that decrease theophylline levels include barbiturates, charcoal, ketoconazole, rifampicin, smoking and sulfinpyrazone. Agents that increase theophylline levels include allopurinol, β-blockers (nonselective), calcium-channel blockers, cimetidine, oral contraceptives, corticosteroids, disulfiram, ephedrine, interferon, macrolides and quinolones.
The concomitant use of salbutamol and other oral sympathomimetic agents is not recommended since such combined use may lead to deleterious cardiovascular effects. Salbutamol should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants because the action of salbutamol on the vascular system may be potentiated. β-receptor-blocking agents and salbutamol inhibit the effect of each other.
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