Dyspep

Dyspep Drug Interactions

simeticone

Manufacturer:

Geno

Distributor:

Nebula

Marketer:

Mascots
Full Prescribing Info
Drug Interactions
FOSPHENYTOIN: Summary: Fosphenytoin is a prodrug of phenytoin and the same interactions that occur with phenytoin are expected to occur with fosphenytoin. McElnay et al (1982) evaluated the effect of concomitant administration of a simethicone-containing antacid on phenytoin bioavailability. In five of six patients evaluated, an insignificant decrease in bioavailability of phenytoin was demonstrated; however, three of the five did experience a decrease of at least 30%. It is unknown to what extent simethicone contributed to this interaction, since the use of antacids as a sole entity can reduce the bioavailability of phenytoin. The authors suggest that clinicians should be aware of this potential interaction, and exercise caution when administering simethicone to patients on phenytoin maintenance therapy.
Severity: Not specified.
Onset: Not specified.
Documentation: Poor.
PHENYTOIN: Severity: Not specified.
Onset: Not specified.
Documentation: Poor.
Literature Reports: McElnay et al (1982) evaluated the effect of concomitant administration of a Simethicone-containing antacid on phenytoin bioavailability. In five of six patients evaluated, an insignificant decrease in bioavailability of phenytoin was demonstrated; however, three of the five did experience a decrease of at least 30%. It is unknown to what extent Simethicone contributed to this interaction, since the use of antacids as a sole entity can reduce the bioavailability of phenytoin.
The authors suggest that clinicians should be aware of this potential interaction, and exercise caution when administering Simethicone to patients on Phenytoin maintenance therapy.
DRUG-LAB MODIFICATIONS: CHEMICAL TEST FOR OCCULT BLOOD: Summary: In an in vitro study, Simethicone interfered with the results of guaiac tests of gastric aspirates (Gogel et al, 1989). Physicians should keep this in mind when interpreting the results of guaiac card tests.
Severity: Minor.
Onset: Rapid.
Documentation: Poor.
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in