Efinaconazole


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Onychomycosis
Adult: For the treatment of cases caused by Trichophyton rubrum and Trichophyton mentagrophytes: As 10% solution: Apply once daily for 48 weeks.
Contraindications
Hypersensitivity.
Special Precautions
Not for ophthalmic, oral, or vaginal administration. Pregnancy and lactation.
Adverse Reactions
Significant: Local pain, irritation, dermatitis.
General disorders and administration site conditions: Application site vesicles.
Skin and subcutaneous tissue disorders: Ingrown toenail.
Patient Counseling Information
Avoid pedicures, use of nail polish, and application of other nail products during treatment.
Monitoring Parameters
Monitor application site for dermatitis, vesicles, pain, and ingrown toenails.
Action
Description: Efinaconazole a triazole derivative, is a synthetic azole antifungal agent. It inhibits 14α-demethylase which causes a decrease in ergosterol concentrations in fungal cell membranes leading to diminished cell membrane integrity and eventually, fungal cell death.
Pharmacokinetics:
Absorption: Absorbed systemically after topical application (low concentrations).
Excretion: Elimination half-life: 29.9 hours.
Chemical Structure

Chemical Structure Image
Efinaconazole

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 489181, Efinaconazole. https://pubchem.ncbi.nlm.nih.gov/compound/Efinaconazole. Accessed Apr. 26, 2021.

Storage
Store between 20-25°C. Protect from heat or flame. Do not freeze.
MIMS Class
Topical Antifungals & Antiparasites
ATC Classification
D01AC19 - efinaconazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
References
Anon. Efinaconazole. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 26/02/2021.

Anon. Efinaconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 26/02/2021.

Buckingham R (ed). Efinaconazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 26/02/2021.

Jublia Solution (Bausch Health Companies Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 26/02/2021.

Jublia Topical Solution, 10% w/w (Kaken Pharmaceutical Co., Ltd.). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 26/02/2021.

Disclaimer: This information is independently developed by MIMS based on Efinaconazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in