Eleron Mechanism of Action






Full Prescribing Info
Pharmacology: Pharmacodynamics: Iron (III)-Hydroxide Polymaltose Complex: Mechanism of Action: Iron is used metabolically in the formation of haemoglobin & is necessary for the oxidative processes of living tissue.
The absorption of ferric Iron from Iron (III)-Hydroxide Polymaltose Complex is controlled by a feedback mechanism. When Iron (III)-Hydroxide Polymaltose Complex comes in contact with the Iron binding sides at the mucosal surface, a physiological exchange is assumed to occur. Iron (III)-Hydroxide Polymaltose Complex releases the required amount of ferric iron, which is actively transported into the mucosal cell by a carrier protein & from there released for binding to ferritin or transferrin.
Folic Acid: Mechanism of Action: Folic Acid supplementation prevents the development of folate deficiency Megaloblastic Anaemia particularly during the third trimester of pregnancy.
Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize Purine and Thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to Methionine via Methionine synthetase.
Pharmacokinetics: Iron (III)-Hydroxide Polymaltose Complex: The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose.
Folic Acid: Protein Binding: Very high to plasma protein.
Route of Elimination: Folic Acid is metabolized in the liver to 7, 8-dihydrofolic acid and eventually to 5, 6, 7, 8- tetrahydrofolic acid with the aid of reduced diphosphopyridine nucleotide (DPNH) and folate reductases. A majority of the metabolic products appeared in the urine after 6 hours; excretion was generally complete within 24 hours. Folic Acid is also excreted in the milk of lactating mothers.
Toxicology: Preclinical Safety Data: Preclinical data reveal no special hazard for humans based on conventional studies of pharmacology, repeated dose toxicity, genotoxicity and carcinogenic potential.
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