Generic Medicine Info
Indications and Dosage
Unstable angina
Adult: Initially, 180 mcg/kg via IV inj, followed by 2 mcg/kg per minute via IV infusion for up to 72 hr. Continue infusion for 18-24 hr after percutaneous coronary intervention (PCI) procedure, up to total max duration of 96 hours of therapy.

Adult: Initially, 180 mcg/kg via IV inj, to be given immediately before procedure, followed by 2 mcg/kg/minute via IV infusion. A second dose of 180 mcg/kg via IV inj should be given 10 minutes after the 1st dose. Continue infusion until hospital discharge or for up to 18-24 hr (minimum treatment duration: 12 hr).
Renal Impairment
Angioplasty: Dose reduction may be needed. See Lit.
CrCl Dosage
<30 Contra-indicated.
Unstable angina: Dose reduction may be needed. See Lit.
CrCl Dosage
<30 Contraindicated.
Active bleeding, increased risk of haemorrhage including hemorrhagic disorders, cerebrovascular disorders, history of stroke, uncontrolled hypertension, severe trauma, severe renal impairment, recent major surgery. Lactation.
Special Precautions
Discontinue in case of serious uncontrolled bleeding, or if emergency surgery or thrombolytic therapy is required. Hepatic impairment, platelet counts <100,000 mm3; hemorrhagic retinopathy, drugs affecting haemostasis. Check aPTT or ACT prior to sheath removal. Severe renal impairment, vasculitis, haemorrhagic retinopathy, acute pericarditis or aortic dissection. Pregnancy.
Adverse Reactions
Bleeding, hypotension; localised Injection site reaction; thrombocytopaenia; back pain; anaphylaxis; GI, intracranial or pulmonary haemorrhage.
IV/Parenteral: B
Drug Interactions
Increased risk of bleeding w/ heparin, other anticoagulants, antiplatelet & thrombolytic agents.
Description: Eptifibatide is a cyclic heptapeptide which blocks the platelet glycoprotein IIb/IIIa receptor thus preventing platelet aggregation and thrombosis. [PubMedID: 21211597]
Onset: Within 1 hr.
MIMS Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
Disclaimer: This information is independently developed by MIMS based on Eptifibatide from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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