Erythromycin + Zinc acetate


Concise Prescribing Info
Indications/Uses
Acne vulgaris.
Dosage/Direction for Use
Adult : Topical As soln: Apply bid to the affected area for 10-12 wk.
Dosage Details
Topical/Cutaneous
Acne vulgaris
Adult: As soln: Apply bid to the affected area for 10-12 wk.
Child: Same as adult dose.
Elderly: Same as adult dose.
Contraindications
Hypersensitivity to erythromycin, zinc acetate, or other macrolide antibiotics.
Adverse Reactions
Rarely, hypersensitivity, pruritus, dry skin, erythema; skin irritation, burning sensation and exfoliation.
Patient Counseling Information
Avoid contact w/ eyes or mucous membranes of the nose and mouth.
Overdosage
Symptoms: Idiosyncratic hypersensitivity. Management: Wash the treated area w/ copious water and simple soap.
Drug Interactions
May occur cross resistance w/ other macrolide group antibiotics, and w/ lincomycin and clindamycin.
Action
Description: Erythromycin exerts its antibacterial activity by inhibiting RNA-dependent protein synthesis at the chain elongation step. It binds to 50S ribosomal subunit which blocks transpeptidation. Zinc induces copper binding protein metallothionein production in enterocytes. Copper binding w/in enterocytes may impair intestinal absorption of dietary copper and reabsorption of endogenously secreted copper in saliva, bile, gastric acid.
Onset: Zinc: Slow.
Pharmacokinetics:
Absorption: Penetrates independently.
Storage
Store below 25°C.
ATC Classification
D10AF52 - erythromycin, combinations ; Belongs to the class of topical antiinfective preparations used in the treatment of acne.
References
Anon. Erythromycin (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/03/2016.

Anon. Zinc acetate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/03/2016.

Joint Formulary Committee. Erythromycin with Zinc acetate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/03/2016.

Disclaimer: This information is independently developed by MIMS based on Erythromycin + Zinc acetate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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