Estriol


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Menopausal HRT 0.5-3 mg/day for 1 mth, then 0.5-1 mg/day. Diagnostic aid in atrophic cervical smear 2-4 mg/day for 7 days before taking the next smear. Infertility due to cervical hostility 0.25-1 mg/day on days 6-15 of the menstrual cycle. Atrophy of the lower urogenital tract related to oestrogen deficiency 4-8 mg/day for the 1st wk, then taper down to 1-2 mg/day. Vag Menopausal atrophic vaginitis As cream (0.01 or 0.1%) or pessary (500 mcg): Apply 500 mcg once daily, reduce to twice wkly subsequently.
Dosage Details
Oral
Menopausal hormone replacement therapy
Adult: 0.5-3 mg daily for 1 mth followed by 0.5-1 mg daily; or 0.25-2 mg daily in combination with other natural oestrogens. A progestogen is required if administered to women with a uterus.

Oral
Infertility due to cervical hostility
Adult: 0.25-1 mg/day on days 6-15 of the menstrual cycle. Increase dose each mth until an optimal effect is obtained.

Vaginal
Menopausal atrophic vaginitis
Adult: As 0.01% or 0.1% cream or 500 mcg pessary: Apply 500 mcg once daily, reduce to twice wkly subsequently.
Administration
May be taken with or without food.
Contraindications
Pregnancy, thrombosis, known or suspected oestrogen-dependent tumors, vag bleeding, history of undiagnosed manifesation of deterioration of otosclerosis during pregnancy or previous use of steroids.
Special Precautions
Thrombosis, severe liver disorders, porphyria, history during pregnancy or previous use of steroids of severe pruritus, cholestatic jaundice, herpes gestationis or otosclerosis. Lactation.
Adverse Reactions
Breast tension or pain, nausea, spotting. Fluid retention, cervical hypersecretion.
Drug Interactions
Reduced efficacy may occur when used with activated charcoal, barbiturates, carbamazepine, griseofulvin, hydantoin and rifampicin. May possibly change efficacy of oral anticoagulants and increase pharmacologic effects of succinylcholine, theophyllines and troleandromycin.
Lab Interference
Reduce responses to metyrapone test. May interfere with thyroid function and glucose tolerance tests.
Action
Description: Estriol is a naturally occurring oestrogen. It induces normalization of vag epithelium. It is claimed to have only a mild proliferative effect on the endometrium. It only has a short retention time in the nuclei of endometrial cells.
Disclaimer: This information is independently developed by MIMS based on Estriol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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