Initially 40 mg once daily. May be increased to 80 mg once daily in patients who do not achieve serum uric acid <6 mg/dL after 2 wk. Gout flare prophylaxis w/ NSAID or colchicine is recommended for up to 6 mth.
Not recommended for asymptomatic hyperuricemia. Concurrent prophylactic treatment w/ NSAID or colchicine is recommended to prevent gout flares at initiation of treatment. Monitor for signs & symptoms of MI & stroke. Assess liver function at 2 & 4 mth following initiation of treatment & periodically thereafter. May affect ability to drive & use machines. Not to be used during pregnancy & lactation.