Fenoverine


Concise Prescribing Info
Indications/Uses
As an antispasmodic.
Dosage/Direction for Use
Adult : PO 100 mg 3 times/day or 200 mg twice daily for not >6 wk.
Dosage Details
Oral
Antispasmodic
Adult: 100 mg tid or 200 mg bid for not >6 wk.
Elderly: Max: 100 mg tid.
Administration
Should be taken with food.
Contraindications
Hypersensitivity, chronic liver disease, history of hyperthermia during or after anaesthesia or after physical effort, renal insufficiency, mitochondrial myopathy, pregnancy, lactation.
Special Precautions
In patients with renal or hepatic insufficiency and in patients >60 yr or with multiple drug therapy, in case of unexplained muscular pain or if myopathy is diagnosed.
Adverse Reactions
Myalgias, reversible rhabdomyolysis, gastric upset.
Action
Description: Fenoverine is a non-anticholinergic synchronizer of smooth muscle motility. It modulates calcium gradient across the muscular cell membrane by regulating the influx of the extracellular calcium and/or release of the intracellular pool. Therefore, fenoverine effectively inhibits the asynchronous spasmodic contractions without appreciable interferences with the physiological synchronous motility of the intestine.
Pharmacokinetics:
Absorption: Oral: Well absorbed.
Storage
Store below 25°C.
MIMS Class
Disclaimer: This information is independently developed by MIMS based on Fenoverine from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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