Monitor CNS effects (e.g. stimulation or depression).
Increased plasma levels w/ ketoconazole or erythromycin. Increased CNS effect w/ other sympathomimetic amines. Increased ectopic pacemaker activity w/ digitalis. Decreased plasma levels w/ Al and Mg containing antacids. May reduce the effect of antihypertensive drugs which interfere w/ sympathetic activity (e.g. methyldopa, mecamylamine, reserpine). Potentially Fatal: Enhanced hypertensive effect w/ MAOIs.
Reduced bioavailability and exposure w/ grapefruit, orange and apple juice.
Description: Fexofenadine is a selective peripheral H1-receptor antagonist thus, inhibits antigen-induced bronchospasm and histamine release. Pseudoephedrine exerts decongestant effect on the nasal mucosa. Pharmacokinetics: Absorption: Fexofenadine: Rapidly absorbed from the GI tract. Time to peak plasma concentration: 2-3 hr. Pseudoephedrine: Readily absorbed from the GI tract. Distribution: Fexofenadine: Plasma protein binding: Approx 60-70%. Pseudoephedrine: Enters breast milk (small amounts). Metabolism: Fexofenadine: Hepatically (approx 5% of the total dose). Pseudoephedrine: Hepatically (<1% of the total dose). Excretion: Fexofenadine: Via faeces (80%), urine (11%). Elimination half -life: Approx 14 hr. Pseudoephedrine: Via urine (55-75%, as unchanged drug). Elimination half-life: Approx 5-8 hr.
R01BA02 - pseudoephedrine ; Belongs to the class of systemic sympathomimetic preparations used as nasal decongestants. R06AX26 - fexofenadine ; Belongs to the class of other antihistamines for systemic use.
Allegra-D 24 Hour Tablet, Film Coated (Sanofi-Aventis U.S. LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 29/06/2015.Anon. Fexofenadine and Pseudoephedrine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 29/06/2015.Buckingham R (ed). Fexofenadine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 29/06/2015.Buckingham R (ed). Pseudoephedrine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 29/06/2015.