Pacific Pharma (Korea)


AA Medical
Concise Prescribing Info
Upper & lower UTI; lower resp tract infections; uncomplicated urethral & cervical gonorrhoea; non-gonococcal urethritis & cervicitis; skin & soft tissue infections.
Dosage/Direction for Use
Adult 200-800 mg daily, up to 400 mg single-dose preferably in the morning, in 2 divided doses for larger doses. Lower UTI 200-400 mg daily. Upper UTI 200-400 mg daily increased if necessary, up to 400 mg bd. Lower resp tract infections 400 mg daily increased, if necessary up to 400 mg bd. Uncomplicated urethral & cervical gonorrhoea 400 mg single-dose. Non-gonococcal urethritis & cervicitis 400 mg daily in single or divided doses. Skin & soft tissue infections 400 mg bd. Renal impairment (CrCl 20-50 mL/min) 100-200 mg daily. (CrCl <20 mL/min) 100 mg 24 hrly. Hemodialysis or peritoneal dialysis 100 mg 24 hrly. Treatment duration: 5-10 days except in uncomplicated gonorrhoea. Max: 2 mth.
May be taken with or without food: Take 2 hr before or after antacids or supplements containing Fe or Zn. Ensure adequate hydration.
Hypersensitivity to 4-quinolone antibacterials. History of tendonitis, epilepsy or w/ a lowered seizure threshold. Potential hemolytic reactions in patients w/ G6PD deficiency. Pregnancy & lactation. Childn & adolescents.
Special Precautions
Patients w/ known risk factors for QT interval prolongation eg, uncorrected electrolyte imbalance (eg, hypokalemia, hypomagnesemia), congenital long QT syndrome, acquired QT prolongation, cardiac disease (eg, heart failure, MI, bradycardia) & concomitant use of class IA & II antiarrhythmics, TCAs, macrolides. Avoid exposure to strong sunlight & UV rays (sun lamps, solaria). Psychotic patients or w/ history of psychiatric disorder. Peripheral neuropathy. Monitor regularly for potential proliferation of microorganism-resistance. May affect ability to drive & use machinery. Elderly.
Adverse Reactions
GI effects: Nausea, vomiting, diarrhoea, abdominal pain, gastric symptoms; diarrhoea may occur as a symptom of enterocolitis. CNS effects: Headache, dizziness, sleep disorders, restlessness.
Drug Interactions
Prolonged QT interval w/ class IA & III antiarrythmics, TCAs, macrolides. Reduced absorption w/ Mg or Al antacids, sucralfate, Zn or Fe prep. Concomitant use w/ anticoagulants may prolong bleeding time. Additive effects in concurrent use w/ seizure-threshold lowering drugs.
MIMS Class
ATC Classification
J01MA01 - ofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Flox-O FC tab 200 mg
10 × 10's
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