Adult 200-800 mg daily, up to 400 mg single-dose preferably in the morning, in 2 divided doses for larger doses.
Lower UTI 200-400 mg daily.
Upper UTI 200-400 mg daily increased if necessary, up to 400 mg bd.
Lower resp tract infections 400 mg daily increased, if necessary up to 400 mg bd.
Uncomplicated urethral & cervical gonorrhoea 400 mg single-dose.
Non-gonococcal urethritis & cervicitis 400 mg daily in single or divided doses.
Skin & soft tissue infections 400 mg bd.
Renal impairment (CrCl 20-50 mL/min) 100-200 mg daily.
(CrCl <20 mL/min) 100 mg 24 hrly.
Hemodialysis or peritoneal dialysis 100 mg 24 hrly. Treatment duration: 5-10 days except in uncomplicated gonorrhoea. Max: 2 mth.
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