Flumetasone + Clioquinol


Concise Prescribing Info
Indications/Uses
Inflammation of the external ear w/ suspected secondary infection.
Dosage/Direction for Use
Adult : Otic As soln containing flumetasone pivalate 0.02% and clioquinol 1%: Instill 2 or 3 drops bid into the auditory canal for 7-10 days.
Dosage Details
Otic/Aural
Inflammation of the external ear with suspected secondary infection
Adult: As soln containing flumetasone pivalate 0.02% and clioquinol 1%: Instill 2 or 3 drops bid directly into the auditory canal of the affected ear for 7-10 days. Patient should be seated or lying down w/ the treated ear turned upwards during application. Maintain this position for at least 1-2 min after application.
Child: ≥2 yr Same as adult dose.
Contraindications
Perforation of the tympanic membrane, disorders associated w/ therapy-resistant secondary infection, iodine sensitivity, primary bacterial, viral, or fungal infection of the outer ear. Childn <2 yr.
Special Precautions
Patient w/ thyroid abnormalities. Childn. Pregnancy and lactation.
Adverse Reactions
Endocrine: Adrenal suppression (prolonged use).
Ophthalmologic: Increased risk of cataract.
Dermatologic: Skin atrophy, telangiectasia, purpura, striae, dermatitis, skin depigmentation, hair colour changes, hypertrichosis, application site burning or irritation, rash, pruritus, impaired healing.
Immunologic:Hypersensitivity, manifestations of bacterial, viral, or fungal infection.
Patient Counseling Information
This drug may cause discolouration of skin, hair, and cloth. Avoid application to the eye.
Lab Interference
May interfere w/ thyroid function tests (e.g. PBI, radioactive iodine and butanol extractable iodine). May cause false-positive ferric chloride test for phenylketonuria.
Action
Description: Flumetasone pivalate is a moderately potent glucocorticoid, usually used for local application. It has an anti-inflammatory, anti-allergic, vasoconstrictive and anti-proliferative effect. Clioquinol, is a halogenated hydroxyquinoline derivative which exerts its bacteriostatic action by chelating bacterial surface and trace metals needed for bacterial growth.
Pharmacokinetics:
Absorption: Clioquinol: Approx 1.5-4% is absorbed.
Excretion: Clioquinol: Via urine, mainly as glucuronide, and as sulfate (small amounts).
Chemical Structure

Chemical Structure Image
Flumetasone

Source: National Center for Biotechnology Information. PubChem Database. Flumethasone, CID=16490, https://pubchem.ncbi.nlm.nih.gov/compound/Flumethasone (accessed on Jan. 21, 2020)


Chemical Structure Image
Clioquinol

Source: National Center for Biotechnology Information. PubChem Database. Clioquinol, CID=2788, https://pubchem.ncbi.nlm.nih.gov/compound/Clioquinol (accessed on Jan. 21, 2020)

Storage
Store below 25°C.
References
Anon. Clioquinol and Flumethasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/03/2017 .

Joint Formulary Committee. Clioquinol with Flumetasone Pivalate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/03/2017 .

Disclaimer: This information is independently developed by MIMS based on Flumetasone + Clioquinol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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