Skin and soft tissue infections, empyema, toxic shock syndrome due to Staphylococcus aureus. Treatment of hospital-acquired Staphylococcus epidermidis infection. Pre- and postoperative care with advantage of parenteral to oral single antibiotic therapy. For chronic administration in bone and joint infections eg, osteomyelitis, endocarditis, along with aminoglycosides, eg amikacin in open heart surgery as prophylaxis. Mild to moderate infections of respiratory tract, genitourinary and gastrointestinal tract.